Serum IgG antibodies to Helicobacter pylori in patients with recurrent aphthous stomatitis and other oral disorders

Abstract

Objectives. To compare the frequency of serum anti-Helicobacter pylori IgG antibodies in patients with recurrent aphthous stomatitis with patients with other oral ulcerative and nonulcerative disorders.Study design. Prospective study of serum IgG antibodies to H. pylori in 75 patients with recurrent aphthous ulcers, 15 patients with other oral ulcerative disorders, 41 patients with other oral mucosal lesions, 27 patients with oral dysaesthesia, and 25 healthy control patients without oral lesions.Results. The frequency of anti-H. pylori seropositivity was not significantly greater in patients with recurrent aphthous stomatitis (30.6%) compared with patients with other ulcerated oral mucosal lesions (33.0%) and controls (24%).Conclusions.Helicobacter pylori does not appear to be of etiologic significance in the development of recurrent aphthous stomatitis.