Abstract
Changes in serum human growth hormone (HGH), immunoreactive insulin, and blood sugar were measured during an intravenous glucose tolerance test (IVGTT) in 31 normal subjects and 17 patients with acromegaly (all but 2 patients previously treated by X-ray). It was found: (1) During IVGTT, HGH levels in normal males were strikingly lower than in normal females, (2) Fasting HGH levels of normal and acromegalic females exhibited considerable overlap. However, 60 minutes following intravenous injection of glucose, the serum HGH decreased in normal females; whereas in patients with acromegaly it remained high, thus permitting differentiation between the 2 groups. (3) Fourteen out of 17 patients with acromegaly showed moderate to severe impairment of glucose utilization, and 3 were overt diabetics. (4) In 5 patients, HGH levels and carbohydrate tolerance were tested before and after X-ray treatment. Only in one of them was a distinct improvement observed, documented by decreased HGH level and increased K rate of glucose disappearance.
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