Abstract
Objective: The present study was conducted for the purpose of setting forth the normal serum Hcy, vitamin B 12 and folate levels in Van cats of varying ages and genders, and the age-dependent variations of these parameters. Materials and methods: The material of the study consisted of a total of 60 healthy Van cats including 30 female and 30 male cats. Cats from both genders were separated into 3 groups on the basis of their ages. While the cats of 6 - 12 months of age were included in the first group, cats of 12-24 months of age were included in the second and those of more than 24 months of age were included in the third group. Results: From the blood samples collected; serum normal homocysteine, vitamin B 12 and folate levels were determined as 7.1±2.2 nmol/mL, 850.7±231.8 pg/mL and 16.7±0.8 ng/mL, respectively. In the statistical comparison of the determined serum homocysteine, vitamin B 12 and folate levels; some variations among different groups of age and genders were determined. However, none of these differences were determined to be statistically significant. Conclusion: The normal levels of serum Hcy, vitamin B 12 and folate of healthy Van cats were set forth for the first time by the present study. It is believed that the normal values of these parameters in Van cats can be used in the diagnosis and prognosis of various diseases and particularly cardiovascular diseases, that they will be helpful for researchers and will serve as a guideline to the studies to be conducted in the future. http://doi.org/10.5455/javar.2017.d191
Highlights
Turkish Van cat is a significant endemic cat species living in the area of Van province of Turkey and attracting great attention all around the world
It is believed that the normal values of these parameters in Van cats can be used in the diagnosis and prognosis of various diseases and cardiovascular diseases, that they will be helpful for researchers and will serve as a guideline to the studies to be conducted in the future
It is reported that Hcy levels increase in cases of folic acid, vitamin B6 and vitamin B12 deficiencies, and that these vitamins are essential for Hcy metabolism (Lippi and Plebani, 2012; Nursalim et al, 2013; Geesaman et al, 2016)
Summary
Turkish Van cat is a significant endemic cat species living in the area of Van province of Turkey and attracting great attention all around the world. With qualities of having odd colored eyes, being affectionate, the white and silky fur and being quite fond of water, Van cats have built a well-earned reputation worldwide Due to their diminishing numbers in the recent years, they have been taken into protection and subjected to many scientific studies (Sonmez and Agaoglu, 2010; Ozkan et al, 2013; Kayar et al, 2014). It is known that there are close relations between Hcy and folic acid, B6 and B12 vitamins In the body it is metabolized through remethylation where folic acid and vitamin B12 serves as cofactors and transsulfuration where vitamin B6 is the cofactor (Aksoy et al, 2006; Nursalim et al, 2013; Ganguly and Alam, 2015). It is reported that Hcy levels increase in cases of folic acid, vitamin B6 and vitamin B12 deficiencies, and that these vitamins are essential for Hcy metabolism (Lippi and Plebani, 2012; Nursalim et al, 2013; Geesaman et al, 2016)
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