Abstract
Background Hyperhomocysteinemia is a well-known cardiovascular risk factor and its elevation is established in overt hypothyroidism. Since some authors suggest that chronic autoimmune thyroiditis per se may be considered as a novel risk factor of atherosclerosis independent of thyroid function, the analysis of classical cardiovascular risk factors might be helpful in evaluation the causative relationship. Data concerning the impact of thyroid autoimmunity in euthyroid state on homocysteine (Hcy) level is lacking. The aim of this study was to evaluate Hcy level in context of anti-thyroperoxidase antibodies (TPOAbs) in euthyroidism.
Highlights
Hyperhomocysteinemia is a well-known cardiovascular risk factor and its elevation is established in overt hypothyroidism
The main finding of the study is a decrease in Hcy level in treated Hashimoto thyroiditis (HT) as compared with healthy controls
A few studies which were addressing this question investigated the effect of thyroid autoimmunity on lipid profile, abdominal obesity, fasting glucose and homeostasis model assessment (HOMA) insulin resistance, as well as carotid intima-media thickness (CIMT) [25,26,27]
Summary
Hyperhomocysteinemia is a well-known cardiovascular risk factor and its elevation is established in overt hypothyroidism. Data concerning the impact of thyroid autoimmunity in euthyroid state on homocysteine (Hcy) level is lacking. Hcy has been investigated as a risk factor for cardiovascular disease since 1969, when McCully observed that two patients with homocystinuria were affected with extensive atherosclerosis and arterial thrombosis [2]. Since the association between elevated level of Hcy and increased risk of coronary heart disease was established [3,4], the issue whether there is a causal relation still remains unclear [5,6]. The possible association between hypothyroid state and Hcy concentration was suggested. Increased Hcy level in overt hypothyroidsm was found in many studies [7,8,9]. In sharp contrast with the above mentioned results, decreased Hcy concentration was found in hyperthyroidism [11]
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