Serum Homocysteine and Reactive Species Levels in Fragility Fractures of the Pelvis

Alexandru Filip,Nina Filip,Gabriela Puha,Cristina Iancu,Ovidiu Alexa,Oana Viola Badulescu,Elena Cojocaru,Paul Dan Sirbu,Mioara Florentina Trandafirescu,Laura Trandafir

doi:10.37358/rc.19.9.7520

Abstract

Although there are studies showing the link between homocysteine and bone quality, the relationship remains controversial. The purpose of the study was to investigate homocysteine levels in patients with fragility fractures of the pelvis and their association with serum Total Antioxidant Status.The study included a group of 60 patients, aged ]65years, with pelvic fragility fractures and osteoporosis admitted in our trauma department between January 2015 and January 2018 and a control group of 30 patients, aged ]65years without fragility fractures or osteoporosis.The total antioxidant status (TAS) and homocysteine (Hcy) concentrations were determined in serum of all the patients. TAS levels had a significantly lower values in the group with pelvic fragility fractures compared with the control group (p[0.001).We noticed a significant higher mean of Hcy levels (p[0.001) in patients with pelvic fragility fractures compared with the control group. As conclusion this study shows that patients with fragility fractures of the pelvis have moderately elevated levels of homocysteine and reduced serum Total Antioxidant Status.

Highlights

There are studies showing the link between homocysteine and bone quality, the relationship remains controversial
Data given as mean±SD There were no significant differences in age, height, weight, current smoking and coffee consumption between control group and patients with osteoporosis
Ethnicity, physical activity, drinking, smoking, estrogen, Ca and vitamin D have a negative impact on bone mineral density and increase the chances of fractures of fragility

Summary

Introduction

There are studies showing the link between homocysteine and bone quality, the relationship remains controversial. As conclusion this study shows that patients with fragility fractures of the pelvis have moderately elevated levels of homocysteine and reduced serum Total Antioxidant Status. Osteoporosis and associated fractures are a major public health concern due to morbidity, mortality, loss of function and decrease the quality of life. Osteoporosis is characterized by bone demineralisation and loss of resistance that leads to fractures due to fragility. Fragility fractures of the pelvis are the result of a lowenergy impact but they can occur spontaneously in elderly people with osteoporosis [1]. Most of the basic fragility fractures, occur due to minor trauma, show minimal displacement and does not usually require surgical treatment.

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