Serum HMGB-1 level and its correlation with p53 and clinical pathology in patients with liver cancer

Abstract

Objective To investigate the serum level of high mobility group box-1(HMGB-1) in patients with liver cancer and its correlation with p53 and clinical pathological features of liver cancer.Methods Serum levels of HMGB-1 and p53 were determined by ELISA in 20 patients with hepatocellular carcinoma,20 with cholangiocellular carcinoma and 20 healthy volunteers.Results Serum HMGB-1 levels in hepatocellular carcinoma patients([83.8±17.4] ng/ml) and cholangiocellular carcinoma patients([95.9±21.4] ng/ml) were significantly higher than that in the healthy volunteers([8.4±2.6] ng/ml,P0.05). Serum p53 levels in hepatocellular carcinoma patients([251.0±45.6] pg/ml) and cholangiocellular carcinoma patients([267.8±47.4] pg/ml) were also significantly higher than that in the healthy volunteers([160.0±28.4] pg/ml,P0.05). Serum HMGB-1 level was positively correlated with the serum p53 level in the hepatocellular carcinoma patients(r=0.660 3,P0.05) and cholangiocellular carcinoma patients(r=0.614 2,P0.05).Serum HMGB-1 and p53 levels were not correlated with the age,gender,tumor size,or number of tumors(P0.05),but were correlated with the TNM stage,differentiation degree and metastasis status(P0.05).Conclusion Serum HMGB-1 level is positively correlated with p53,and both HMGB-1 and P53 influence the pathogenesis of liver cancer.