Abstract
To evaluate the clinical significance of serum levels of hepatocyte growth factor (HGF) in colorectal cancer patients, we measured the venous and portal concentrations of HGF in 60 patients. The tissue concentrations in the tumour and adjacent normal mucosa were also determined. The serum HGF concentration for the peripheral venous blood of the patients was significantly higher than that in normal controls. The content of HGF in cancer tissue was also significantly higher than that in normal mucosa, and it was correlated with the serum HGF concentration for the peripheral venous blood. The serum concentration of HGF reflected pathological features, including tumour size and lymph node or liver metastasis, and it showed an association with various preoperative nutritional parameters and the preoperative haemoglobin level. The serum HGF concentration was also correlated with the serum concentrations of immunosuppressive acidic protein and interleukin-6, indices of the host's immunological condition. Serum HGF seems to be a useful index of the disease status of patients with colorectal carcinoma.
Highlights
The serum carcinoembryonic antigen (CEA) level in the peripheral venous blood was elevated in 27 patients (45%)
There was a significant correlation between the serum concentration of hepatocyte growth factor (HGF) and IL-6, suggesting that the cancer-stroma interaction through IL-6 and HGF may exist in colorectal carcinoma
Our findings suggest that the serum HGF concentration in the peripheral venous blood may reflect the content of HGF in the tumour component, and that the increase in the circulating level may be associated with tumour proliferation
Summary
The objective of this study was to evaluate the relationship between serum HGF concentration and clinicopathological parameters in patients with colorectal cancer
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