Abstract
Heme oxygenase-1 (HO-1) is induced by various types of oxidative stress. We have investigated, among cardiac patients, whether serum HO-1 concentration was incresaed in patients with high serum uric acid (UA) and low renal function, conditions that are thought to be associated with increased oxidative stress. Serum HO-1 was measured using ELISA system. Serum HO-1 levels were found to be correlated with serum UA (R=0.61, P=0.017, Figure) and estimated GFR (eGFR) (R=0.55, P=0.026, by Spearman's test). On the other hand, serum HO-1 did not, although UA did, have significant association with left ventricular ejection fraction (Figure). Serum HO-1 level was elevated in patients with high UA and low eGFR. Circulating HO-1 may represent a useful biomarker for in vivo oxidative stress among cardiac patients.
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