Abstract
Introduction: Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and accompanied by long term damage, dysfunction and failure of various organs. Several studies have shown that Glycated Albumin (GA) is more reliable DM monitor and a better marker of glycemic control in patients with fluctuating and poorly controlled type 2 DM. Moreover, serum GA is not affected by factors that affect hemoglobin metabolism. The aim of the study: To study the value of serum glycated albumin as a new marker for glycemic control in diabetic children. Methods: 30 diabetic children were included in the study in addition to 20, sex and age matched apparently healthy children as a control group. The associations among HbA1c, GA, and GA/HbA1c ratio were examined, referred and managed in Children’s Hospital, Minia University. The results: Plasma glucose, GA and HbA1c measurements were done at baseline, after the 1st and after the 3rd months for all the subjects. GA levels strongly correlated with HbA1c% in the diabetic group. The mean GA and HbA1c values were significantly lower in control group than in diabetic group (p<0.001). GA, HbA1c and the ratio decreased significantly within 4 weeks, but GA showed a significantly larger decrease than HbA1c. Conclusion: GA seems to be more accurately reflect short term glycemic control than HbA1c.
Highlights
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and accompanied by long term damage, dysfunction and failure of various organs
The aim of this work was to study the value of serum Glycated Albumin (GA) as a new marker for glycemic control in diabetic children
The combination of severe insulin deficiency and physical and psychosocial changes makes the management of children T1DM difficult [7]
Summary
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and accompanied by long term damage, dysfunction and failure of various organs. The aim of the study: To study the value of serum glycated albumin as a new marker for glycemic control in diabetic children. The chronic hyperglycemia of diabetes is associated with long term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart and blood vessels [1]. HbA1c is widely used for evaluation of long-term glycemic control and it provides an index of average blood glucose level during the past 2-3 months [3]. The use of HbA1c has some limitations as it may not be suitable for short term glycemic control and in conditions that affect Hb metabolism as anemia [4].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
