Serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase variations with their Pearson’s coefficient correlation in sickle cell disease

Abstract

Background: The sickle cell disease condition with hepatic dysfunction shows the abnormal variations in liver function tests including serum aminotransferases enzymes like serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels were changed to discuss their significance in the sickle cell disease. Objectives: Studied of SGOT and SGPT level variation in sickle cell disease, and Pearson’s correlation coefficient of SGOT& SGPT in sickle cell disease. Material and methods: This study was conducted in the Department of Biochemistry, People’s College of Medical Sciences and Research Centre and Centre for Scientific Research and Development Department (CSRD), People’s University, Bhopal. The liver enzymes SGOT and SGPT were estimated by Reitman & Frankel’s method and were diagnosed. Results: In the present study, the mean standard deviation of cases vs. controls were showed significant difference and it was calculated by using the SPSS software version-24. The mean ± SD cases vs controls of SGOT and SGPT were found in 69.98 ± 69.31; 25.17± 5.25 and 65.28 ± 60.07; 22.72 ± 5.47 respectively. The calculated P˂0.000 was found to be statistically highly significant. The Pearson’s Correlation showed positive correlation in between SGOT and SGPT enzymes. Conclusion: The transaminases SGOT and SGPT enzymes were significantly increased in sickle cell disease so it could be another clinical bio-marker for the diagnosis of sickle cell disease. Keywords: SGOT; SGPT; Pearson’s correlation; sickle cell disease