Serum glutamate in rhesus macaques after gavage with MSG

Abstract

Administration of monosodium glutamate (MSG) to rhesus monkeys caused a dose-related increase in serum glutamate concentration, and Na + concentration is also increased when large quantities of MSG are ingested. Vomiting occurs in 50% of treated monkeys but is not precisely correlated with serum glutamate levels. The concentration of glutamate in vomitus reflects the dosage of MSG given. Monkeys with enteritis have high basal serum glutamate levels.