Abstract
Antioxidant plays an important role in preventing the progression of diabetes mellitus (DM) complications. This study was undertaken to evaluate the hypoglycemic effect of glutathione complex in Alloxan induced diabetic rats. Thirty albino rats (weighing 120-130g) were divided into six groups of five rats each: Group one serves as normal control, group two served as diabetic control while Group three, four and five were diabetic and administered with 2.4mg/kg body weight, 3.6mg/kg body weight and 4.8mg/kg body weight respectively. All treatments were administered orally for 4 weeks on daily basis. Serum glucose level was measured at an interval of three days throughout the period of the experiment. Results obtained showed that administration of Glutathione Complex to diabetic rats caused a significant decrease (p<0.05) in serum glucose level compared to diabetic control. These results suggest that administration of Glutathione Complex to diabetic rats may help reverse the complications of diabetes mellitus. Keywords: Alloxan, Diabetes, Glucose and Glutathione Complex DOI: 10.7176/ALST/84-03 Publication date: December 31 st 2020
Highlights
The incidence of diabetes mellitus (DM) is prevalent over all parts of the world
From the animals subjected to diabetes induction, 73% developed severe diabetes mellitus; 20% developed mild condition; and the remaining 7% died within the first week of follow up, probably due to acidosis
Alloxan induced diabetes is characterized by hyperglycemia and a severe loss in body weight (Chen and Ianuzzo,1982) and may exhibit most of the diabetic complications such as, myocardial, cardiovascular, gastrointestinal, nervous, kidney and urinary bladder dysfunction through oxidative stress (Rajasekaran et al, 2005)
Summary
The incidence of diabetes mellitus (DM) is prevalent over all parts of the world. It is associated with reduced quality of life and increased mortality and morbidity factors. Diabetes mellitus is a multi-faceted metabolic disorder where there is increased oxidative stress that contributes to the pathogenesis of this debilitating disease. This has prompted several investigations into the use of antioxidants as a complementary therapeutic approach (mandrup-poulsen, 1998). Hyperglycemia leads to increase in oxidative stress due to the overproduction of free radicals and decreased efficiency of antioxidant defense system. It occurs in patients with poor glycemic control (Wiernsperger, 2003). The stability and capacity of antioxidant status during chronic diabetes seriously influences the outcome of the long-term complications caused by oxidative stress
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