Abstract
The clinical history and physical signs are not reliable or sensitive indices of the presence of hepatocellular damage, or of its progress when found. Thus the detection of parenchymatous liver disease and the study of a patient's progress when hepatic involvement has been detected have come to depend more upon the use of sensitive biochemical tests of liver function. To us, it seemed desirable to have a method of analyzing serum protein structure in liver disease in term of physiological variables rather than in terms of flocculation tests which reflect multiple factors. Electrophoretic analysis is entirely too cumbersome for general use. The older salt fractionation procedures, such as the Howe method, are grossly erroneous. However, we recently reported a rapid chemical fractionation method for the estimation of albumin and of the three major globulin fractions in serum, which is suitable for clinical use1• This procedure yields results which approximate those of electrophoretic analysis. The present study was carried out to determine whether, when this technique of serum protein fractionation was carried out under routine conditions on a group of patients with liver disease, we could detect characteristic abnormalities of protein patterns which might aid in detecting and following liver disease in such patients.
Published Version
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