Abstract
Dengue fever is a serious threat for public health and induces various inflammatory cytokines and mediators, including galectins and glycoproteins. Diverse immune responses and immunological pathways are induced in different phases of dengue fever progression. However, the status of serum galectins and glycoproteins is not fully determined. The aim of this study was to investigate the serum concentration and potential interaction of soluble galectin-1, galectin-3, galectin-9, galectin-3 binding protein (galectin-3BP), glycoprotein 130 (gp130), and E-, L-, and P-selectin in patients with dengue fever in acute febrile phase. In this study, 317 febrile patients (187 dengue patients, 150 non-dengue patients that included 48 patients with bacterial infection and 102 patients with other febrile illness) who presented to the emergency department and 20 healthy controls were enrolled. Our results showed the levels of galectin-9 and galectin-3BP were significantly higher in dengue patients than those in healthy controls. Lower serum levels of galectin-1, galectin-3, and E-, L-, and P-selectin in dengue patients were detected compared to bacteria-infected patients, but not to healthy controls. In addition, strong correlation between galectin-9 and galectin-3BP was observed in dengue patients. In summary, our study suggested galectin-9 and galectin-3BP might be critical inflammatory mediators in acute dengue virus infection.
Highlights
Dengue fever is a mosquito-borne viral disease and is caused by dengue virus [1]
A total of 317 febrile patients including 187 dengue patients, 150 non-dengue patients which included 48 patients with bacterial infection and 102 patients with other febrile illness (OFI)), and 20 healthy controls were studied between November 2013 and November 2015 (Table 1)
Our results showed the level of E-selectin in dengue patients was not significantly different from healthy controls
Summary
Dengue fever is a mosquito-borne viral disease and is caused by dengue virus (type I–IV) [1]. A statistical report from World Health Organization indicates the incidence of dengue fever has been significantly rising in the past 50 years [2]. In recent decades, the impact of dengue has increased geographically in tropical and subtropical areas including Taiwan [3,4]. More than 30,000 dengue patients were reported in Kaohsiung from 2014 to 2015 according to the statistics of the Taiwan National Infectious Disease Statistics System [5]. The outbreak dengue virus is mainly genotype I and serotype I in Kaohsiung [6]. It is a serious threat in southern Taiwan and other tropical areas
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