Abstract
Background Halogenative and nitrosative stress are two types of oxidative stress that have been proposed as pathogenic mechanisms in Parkinson’s disease (PD). They can be caused by over-stimulation of phagocytes. We hypothesize that maintained phagocyte overstimulation leads to both halogenative and nitrosative stress in Parkinson’s disease, which are present in serum and cerebrospinal fluid of patients. These types of oxidative stress could modify proteins related to the pathogenesis of Parkinson’s disease.
Highlights
Halogenative and nitrosative stress are two types of oxidative stress that have been proposed as pathogenic mechanisms in Parkinson’s disease (PD)
In our lab, it has been detected the presence of halogenative stress in serum and, to a lesser extent, cerebrospinal fluid of Parkinsonian patients leading to excess of advanced oxidized protein products or AOPP
Nitrosative stress is present in serum and cerebrospinal fluid of patients with early PD, characterized by the selective increase of 3-nitrotyrosine proteins other than nitroalbumin and free 3-nitrotyrosine
Summary
Halogenative and nitrosative stress are two types of oxidative stress that have been proposed as pathogenic mechanisms in Parkinson’s disease (PD). They can be caused by over-stimulation of phagocytes. We hypothesize that maintained phagocyte overstimulation leads to both halogenative and nitrosative stress in Parkinson’s disease, which are present in serum and cerebrospinal fluid of patients. These types of oxidative stress could modify proteins related to the pathogenesis of Parkinson’s disease
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