Abstract
BackgroundIt has been reported that higher folate intake from food and supplementation is associated with decreased blood pressure (BP). The association between serum folate concentration and BP has been examined in few studies. We aim to examine the association between serum folate and BP levels in a cohort of young Chinese women.MethodsWe used the baseline data from a pre-conception cohort of women of childbearing age in Liuyang, China, for this study. Demographic data were collected by structured interview. Serum folate concentration was measured by immunoassay, and homocysteine, blood glucose, triglyceride and total cholesterol were measured through standardized clinical procedures. Multiple linear regression and principal component regression model were applied in the analysis.ResultsA total of 1,532 healthy normotensive non-pregnant women were included in the final analysis. The mean concentration of serum folate was 7.5 ± 5.4 nmol/L and 55% of the women presented with folate deficiency (< 6.8 nmol/L). Multiple linear regression and principal component regression showed that serum folate levels were inversely associated with systolic and diastolic BP, after adjusting for demographic, anthropometric, and biochemical factors.ConclusionsSerum folate is inversely associated with BP in non-pregnant women of childbearing age with high prevalence of folate deficiency.
Highlights
Elevated blood pressure (BP) is a well-established risk factor for stroke and coronary heart disease [1], and the relationship between BP and cardiovascular mortality as well as overall mortality is continuous without a threshold [2]
We aim to examine the association between serum folate and BP levels in a cohort of young Chinese women
The mean concentration of serum folate was 7.5 ± 5.4 nmol/L and 55% of the women presented with folate deficiency (< 6.8 nmol/L)
Summary
Elevated blood pressure (BP) is a well-established risk factor for stroke and coronary heart disease [1], and the relationship between BP and cardiovascular mortality as well as overall mortality is continuous without a threshold [2]. Epidemiologic studies suggested that higher folate intake may be associated with decreased BP levels [5,6,7] as well as decreased incidence of hypertension [8, 9]. Animal studies have shown that oral folic acid supplementation improved endothelial function and decreased BP [16,17,18]. These data suggest that folate intake may have an effect on decreasing BP. It has been reported that higher folate intake from food and supplementation is associated with decreased blood pressure (BP). We aim to examine the association between serum folate and BP levels in a cohort of young Chinese women
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