Serum Fibrinogen Assay in Prediction of Postpartum Hemorrhage and its Role in Treatment

Abstract

Background: PPH is postpartum haemorrhage. It is uncommon and severe.1 to 5% of neonates are affected with PPH, the incidence of which varies by age 20 to 30 and socioeconomic level. During pregnancy, fibrinogen levels in plasma increase. Blood loss results in coagulopathy and low fibrinogen concentrations. Premature PPH is associated with severe bleeding and transfusions. FC is produced from human plasma without the need for cross-matching or freezing. Postpartum haemorrhage must coagulate. Problems with coagulation induce PPH. Fluids, blood, and ergotamine are agents that induce uterine contractions. Aim: The aim of the present work was to study the role of serum fibrinogen level as a predictor for postpartum hemorrhage and its role in the treatment. Subjects and Methods: This Prospective observational study was conducted in the obstetrics and gynecology unit of Benha University Hospitals and Tokh Hospital. This study included 50 patients in 3rd trimester (34-37 weeks). The duration of the study ranged from 6-12 months. Results: There was significant difference regarding Logistic regression with odds ratios and 95% confidence intervals (CI) predicting Bleeding severity. Conclusion: The fibrinogen level at PPH diagnosis is a marker of the risk of aggravation and should serve as an alert to clinicians.