Serum Fetuin B Levels and Factors Influencing its Concentrations in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Abstract

The objective of this study is to explore the serum fetuin B levels and factors influencing its concentrations in patients with newly diagnosed type 2 diabetes mellitus (T2DM) and to provide evidence for the prevention of T2DM and its complications. Two hundred three patients with newly diagnosed type 2 diabetes and 209 healthy controls were recruited. The serum fetuin B levels were measured using an ELISA, and the correlations between fetuin B levels and glycosylated hemoglobin levels, insulin resistance index (HOMA-IR), SOD levels, GSH-PX levels, MDA levels, nonalcoholic fatty liver disease and carotid atherosclerosis were analyzed. We obtained the following results: (1) A significantly higher serum fetuin B level was observed in the T2DM group than in the CON group (P < 0.001). (2) The serum fetuin B level positively correlated with the HOMA-IR, HbA1c, TG, APOB, and GSH-PX levels, but it negatively correlated with HDL-C and SOD levels. The multivariate linear stepwise regression analysis showed that HBA1c was an important factor influencing fetuin B levels. (3) According to the logistic regression analysis, fetuin B is a risk factor for T2DM. Finally, we drew several conclusions: 1. The influencing factors for type 2 diabetes mellitus and non-alcoholic fatty liver disease include increased the serum fetuin B level in patients with newly diagnosed type 2 diabetes mellitus and resulted in a much higher serum fetuin B level in the group complicated with NAFLD. 2. The glycosylated hemoglobin level is an important factor influencing fetuin B levels..