Abstract
BackgroundInsulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports were inconsistent.MethodsTwo hundred seven subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t-test or Nonparametric test was used to detect differences between PCOS and control groups. Spearman’s correlation analysis was used to examine the association of the serum Fetuin-A with other parameters.ResultsOur findings showed that circulating Fetuin-A concentration ranged from 196.6 to 418.2 μg/L for most women without PCOS (95%). Women with PCOS had higher circulating Fetuin-A levels than healthy women (437.9 ± 119.3 vs. 313.8 ± 60.5 μg/L; p < 0.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T, and DHEA-S. Multivariate regression analysis showed that WHR, TG, HOMA-IR, and DHEA-S were independent predictors of the levels of circulating Fetuin-A. Binary logistic regression revealed that serum Fetuin-A was associated with the occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 μg/L.ConclusionBlood Fetuin-A may be a useful biomarker for screening women for PCOS and IR.
Highlights
Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS)
Serum Fetuin-A was positively correlated with Body mass index (BMI), waist-to-hip ratio (WHR), TG, total cholesterol (TC), lowdensity lipoprotein cholesterol (LDL-C), homeostasis model assessment of IR (HOMA-IR), luteinizing hormone (LH), T, and dehydroepiandrostenedione sulfate (DHEA-S) (Table 2)
The results showed that the area under the receiver operating characteristic (ROC) curves for PCOS (AUCPCOS) was 0.82 with a specificity of 83.5%, and sensitivity of 69.7% (p < 0.01, Fig. 2a), and AUCIR was 0.80 with a specificity of 81%, and a sensitivity of 72.3%
Summary
Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). Polycystic ovary syndrome (PCOS) is one of the most common endocrine, metabolic diseases in adolescent women. It has three main characteristics: oligo or amenorrhea (OA), hyperandrogenism (HA), and/or clinical manifestations of HA, polycystic ovary (PCO), and most cases are accompanied by obesity and other metabolic disorders. Liu et al BMC Endocrine Disorders (2020) 20:67 phenotypes of PCOS, the relative contribution of excessive androgen and other factors, such as obesity and IR, to the development of PCOS has been manifested in different ways [5]. It is essential to look for circulating biomarkers that reflect metabolic disorders and IR in PCOS patients
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