Serum Fertility Hormonal Levels In Malaria Infected Symptomatic HIV Male Subjects In Nnewi, South Eastern Nigeria.

Abstract

The present study was design to determine the fertility hormonal levels of Luteinizing hormone (LH), Follicle stimulating hormone (LH), Progesterone, Testosterone, Proactin, Estrogen and Cortisol in malaria infected symptomatic HIV stage 11 seropositive male participants aged between 18 and 60 (42±13) years were randomly recruited for this study. Based on World Health Organisation (WHO) criteria for staging HIV, the participants were grouped as follows: 138 symptomatic HIV stage 11 infected male participants, 69 of them had malaria co-infection and 136 HIV seronegative male participants, 68 of them also had malaria co-infection. Blood samples were collected from the participants for the determination of HIV status by Immunochromatography and Immunoprecipitin methods, malaria parasite detection by thick and thin film method. The fertility hormones were also determined by Enzyme Linked Immunosorbent Assay (ELISA) methods. The result showed that the serum FSH, Progesterone, Testosterone, Estrogen and Cortisol levels were significantly different when compared amongst the groups (p<0.05, in each case). Testosterone levels also showed significantly lower values in malaria infected and malaria uninfected symptomatic HIV stage 11 participants not on ART (in each case) compared with malaria infected and malaria uninfected HIV seronegative control participants (p<0.05).The mean FSH levels were significantly different in malaria infected and malaria uninfected symptomatic HIV stage 11 participants not on ART (in each case) compared with malaria infected and malaria uninfected HIV seronegative control participants (p<0.05). The implication of this finding is that HIV-malaria co infection has an effect on the release of LH, FSH and Cortisol levels in symptomatic HIV stage 11 participants.