Objective: This clinical study investigates the potential of serum ferritin levels as a prognostic indicator in acute ischemic stroke. Methods: This cross-section study included 75 patients enrolled in our outpatient clinic, General Medicine Department, and SMS Medical College. The study enrolled all patients who had a new onset focal neurological deficit due to a stroke. A total of 75 patients (25 in each group (mild/moderate/ severe) as per the National Institute of Health Stroke Scale scoring) of >14 years old, presenting in the general medicine wards were enrolled for the study. The study assesses the correlation between serum ferritin levels and various clinical parameters, including stroke severity, consciousness status, and disability outcomes. Results: Severe group had the highest average blood ferritin level (408.48 with a standard deviation (SD) of 68.63). A significant relationship was observed between ferritin levels and loss of consciousness. In addition, the mean ferritin residue ratio (MRS) also correlated with ferritin levels, with MRS correlating to ferritin levels. A significant association between elevated serum ferritin levels and severe stroke, as well as unfavorable outcomes. Conclusion: The findings suggest that serum ferritin could serve as a promising prognostic index in acute ischemic stroke, aiding in patient risk stratification and clinical decision-making.

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