Abstract
BackgroundLiver cirrhosis and the child-Turcotte-Pugh (CTP) score are inseparable entities in liver disease. CTP score is largely known as the mortality and prognosis predictor. Nevertheless, ferritin emerges as a simple biomarker related to prognosis. The study aimed to determine whether there was a significant correlation between serum ferritin levels and CTP score.MethodsThe study analysed 54 decompensated liver cirrhotic patients including 17 females and 37 males between May 2016 and May 2017 at the Haji Adam Malik General Hospital, Medan, Indonesia. Ferritin levels were, then, divided into trichotomous cut-off value (< 200 ng/mL, n = 22; 200–400 ng/mL, n = 5; and > 400 ng/mL, n = 27). Data was analysed using SPSS version 12.0 (continuous variables were assessed by the Kruskal-Wallis test and Chi-square test was used for categorical variables). In addition, Spearman correlation test was used to determine any significant correlation between ferritin levels and CTP score.ResultsBased on data analysis, gender and CTP score were related to higher ferritin levels (P = 0.002 and P = 0.018, respectively). Furthermore, a significant correlation between serum ferritin levels and CTP score was obtained in to moderate degree (P = 0.000; r = 0.487).ConclusionsThere might be a significant role of serum ferritin levels in predicting mortality and prognosis among decompensated liver cirrhosis patients but it still needs further attention.
Highlights
Liver cirrhosis has been established as a condition where normal liver parenchyma was replaced with connective tissue producing nodule formation
The serum ferritin levels were significantly correlated with CTP score (r = 0.487; P = 0.000) (Figure 1)
The significant and positive correlation between serum ferritin levels and CTP score was evident among decompensated liver cirrhosis patients in the study
Summary
Liver cirrhosis has been established as a condition where normal liver parenchyma was replaced with connective tissue producing nodule formation. Since it disrupts liver function, the term used to describe the condition is the endstage of chronic liver disease. Indonesia reduced its HBsAg endemicity to moderate level in 2013 but it still faces multiple problems related to cirrhotic complications. Liver cirrhosis and the child-Turcotte-Pugh (CTP) score are inseparable entities in liver disease. CTP score is largely known as the mortality and prognosis predictor. Ferritin emerges as a simple biomarker related to prognosis. The study aimed to determine whether there was a significant correlation between serum ferritin levels and CTP score
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