Abstract
Existing research yields conflicting results regarding the relation between iron deficiency and high serum ferritin (SF) levels in primary lung cancer patients. We investigated the concentrations of SF, hemoglobin (Hb) and transferrin (TRF) in 569 male primary lung cancer patients and 252 female primary lung cancer patients. We grouped the subjects according to gender, smoking status, menopausal status, pathological type, stage, and TNM stage. The levels of SF and TRF were correlated with T stage in male patients (p<0.01). The levels of SF and TRF were correlated with menopausal status in female patients (p<0.01). Hb was correlated with smoking status, pathological type, stage, and TNM stages in male patients(p<0.01), but in female patients, Hb was not correlated with these grouping factors(p>0.05). The levels of SF may be regulated by different mechanisms and may be of different physiological significance in different populations.
Highlights
Recent work has shown that iron has a role in the tumor microenvironment and in metastasis [1]
We investigated the concentrations of serum ferritin (SF), hemoglobin (Hb) and transferrin (TRF) in 569 male primary lung cancer patients and 252 female primary lung cancer patients
Hb was correlated with smoking status, pathological type, stage, and TNM stages in male patients(p0.05)
Summary
Recent work has shown that iron has a role in the tumor microenvironment and in metastasis [1]. SF is highly expressed in tumor tissues and serum of patients with non-small cell lung cancer [6]. High expression of SF in non-small cell lung cancer may be the result of inflammation and oxidative stress [6]. Infection or inflammation generate anemia and profound changes in iron metabolism, and SF increases with infections [7, 8]. SF levels could be used to differentiate between fever of unknown origin caused by infectious and noninfectious diseases [10, 11]. These changes are important confounders to consider in assessments of SF status
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