Abstract
BackgroundFerritin is one of the key proteins that regulate iron homeostasis and is widely available clinical biomarker of iron status. This study aimed to discuss the influence of serum ferritin (SF) on cardiovascular risk factors in the first-degree relatives with family history of type 2 diabetes (FHD).MethodsThis cross-sectional study included 232 men. Anthropometric measurements and blood samples were analyzed. The people were divided into four groups according to median SF (102.8 ng/ml) and people with or without FHD. Group A (FHD–and low SF), group B (FHD–and high SF), group C (FHD+ and low SF), and group D (FHD+ and high SF).ResultsThe subjects in different categories of SF concentrations showed significant differences in BMI (SF main effect: P = 0.010), WC (P = 0.030), SBP (P < 0.001), FPG (P < 0.001), PPG-2 h (P < 0.001), FINS (P < 0.001), and HOMA-IR (P = 0.015; all: 2-way ANOVA). There was a significant difference in SBP (FHD main effect: P = 0.003), DBP (P = 0.006), and FINS (P = 0.013, all: 2-way ANOVA) between the groups with or without FHD. The interaction term between SF and FHD was significant for SBP (P = 0.011), DBP (P = 0.012), and PPG-2 h (P = 0.022). Logistic analysis showed that accumulation of CVD risk factors, which were ≥ 2 items and ≥ 3 items in group D were 7.546 and 3.343 times higher compared with group A (P < 0.05).ConclusionsThe increased SF levels increased the risk of cardiovascular risk factors and the occurrence of insulin resistance in first-degree relatives with FHD.
Highlights
Ferritin is one of the key proteins that regulate iron homeostasis and is widely available clinical biomarker of iron status
Significant differences in general characteristics across different phenotypes of serum ferritin (SF) concentrations and family history of type diabetes (FHD) were searched by using two-way analysis of variance (ANOVA), and the main effects of SF and FHD and SF × FHD interaction were tested
The subjects in different categories of SF concentrations showed significantly different Body mass index (BMI) (SF main effect: P = 0.010), waist circumference (WC) (P = 0.030), Systolic blood pressure (SBP) (P < 0.001), Fasting plasma glucose (FPG) (P < 0.001), PPG-2 h (P < 0.001), fasting insulin (FINS) (P < 0.001), and homeostasis model assessment (HOMA)-insulin resistance (IR) (P = 0.015; all: 2-way ANOVA), whereas no significant difference was observed for age (P = 0.718), Diastolic blood pressure (DBP) (P = 0.725), TG (P = 0.975), High-density lipoprotein cholesterol (HDL-C) (P = 0.084), and HOMA-β (P = 0.891)
Summary
Ferritin is one of the key proteins that regulate iron homeostasis and is widely available clinical biomarker of iron status. This study aimed to discuss the influence of serum ferritin (SF) on cardiovascular risk factors in the first-degree relatives with family history of type 2 diabetes (FHD). The impact of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) has been increasing over the last decade, and its incidence is estimated to double the present rate by 2025. A family history of type 2 diabetes (FHD) is considered to be a major risk factor for CVD. Metabolic syndrome (MetS) consists of a group of irregularly aggregated metabolic components with clinical characteristics of obesity, abnormally regulated glucose, metabolic disturbance in blood lipids and hypertension. The components of MetS, which are considered as cardiovascular risk factors, directly promote the occurrence of atherosclerosis. The combined effect of MetS and IR contributed to the risk of CVD [4].
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