Abstract
Psoriasis is associated with metabolic syndrome and cardiovascular disease. Fatty acid-binding proteins (FABP) have been recognized as predictors of these systemic disorders. The aim of this study was to assess correlations between levels of serum heart and adipocyte fatty acid-binding proteins (FABP3, FABP4) and disease severity, indicators of inflammation or metabolic disturbances, and topical treatment in psoriatic patients. Thirty-seven patients with relapse of plaque-type psoriasis and 16 healthy volunteers were recruited. Blood samples were collected before and after 14 days of therapy. Serum FABP concentrations were examined by enzyme-linked immunosorbent assay for correlation with Psoriasis Area and Severity Index (PASI), body mass index (BMI), inflammatory or metabolic parameters, and treatment used. The median FABP4 serum levels were significantly increased (p = 0.038) in psoriatic patients, while FABP3 levels did not differ (p = 0.47) compared to the controls. No significant correlations were noted between the proteins and PASI, C-reactive protein (CRP), BMI, or levels of glucose or lipids. FABP3 significantly correlated with white blood count (p = 0.03) and aspartate aminotransferase (p = 0.04). After topical treatment, there was no significant change in serum FABP3 [11.5 (4.9–30.3) vs. 12.9 (3.5–30.3) ng/ml] (p = 0.96), whereas FABP4 was decreased [27,286 (20,344–32,257) vs. 23,034 (18,320–29,874) pg/ml] (p = 0.12), losing its basal significance. FABP4 may be a marker of psoriasis, and FABP3 may be associated with inflammation or liver disorders in psoriatic patients. FABP do not appear to be useful for determining disease severity or the effectiveness of antipsoriatic treatment.
Highlights
Psoriasis is a chronic inflammatory dermatosis with a multifactorial pathogenesis, affecting over 2% of the world’s population
It is extremely difficult to discuss the results obtained in this work when, to the best of our knowledge, there is not a single study in the published literature regarding the role of the heart and adipocyte isoforms of Fatty acid-binding proteins (FABP) in psoriasis, or the relationship with antipsoriatic therapy
The authors suggested that skin-stripping fatty acid-binding protein 5 (FABP5) levels are related instead to local skin condition
Summary
Psoriasis is a chronic inflammatory dermatosis with a multifactorial pathogenesis, affecting over 2% of the world’s population. It has been considered as a systemic disorder closely associated with coronary artery disease (CAD), hypertension, diabetes mellitus (DM), obesity, metabolic syndrome (MS) and atherosclerosis [1, 2]. Psoriatic patients live on average 5 years less than the general population, which is due to increased risk of myocardial infarction (MI) and thromboembolic events [3]. The risk of developing DM, obesity and MS is more than double, occurring in over 40% of psoriatic patients [4]. As well as ours, have demonstrated the potential role of various adipokines in the development of psoriasis and its comorbidities [5, 7]
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