Serum Expression of ESM-1, HMWA, and AGEs and Its Relationship with Disease Severity in Patients with Gestational Hypertension.

Yun Yan,Jieru Xu,Linlin Luan

doi:10.1155/2021/9545857

Abstract

Objective The research is to investigate the expression and the relationship between serum endothelial cell-specific molecular molecule-1 (ESM-1), high molecular weight adiponectin (HMWA), and late glycosylation terminal product (AGEs) in patients with gestational hypertension. Methods 75 patients with pregnant hypertension who were treated in our hospital from June 2019 to June 2020 were selected as the case group, and 70 healthy pregnant women with pregnancy examination at the same period in our hospital were selected as the control group to analyze the changes in serum ESM-1, HMWA, and AGEs levels and the correlation with the degree of illness and their predictive value. Results Serum ESM-1 and AGEs were significantly higher in the case group than in the control group. Serum HMWA was significantly lower than that in the control group (P < 0.05). The gestational hypertensive serum ESM-1 and AGEs was significantly lower than in patients with mild preeclampsia and severe preeclampsia. Serum HMWA was significantly higher than in patients with mild preeclampsia and severe preeclampsia. Serum ESM-1 and AGEs of mild preeclampsia were significantly lower than in patients with severe preeclampsia. Serum HMWA was significantly higher than in patients with severe preeclampsia (P < 0.05). The result of correlation analysis shows a positive correlation between serum ESM-1 and AGEs (P < 0.05). A negative correlation was observed between HMWA and the degree of illness (P < 0.05). Conclusion Serum ESM-1, HMWA, and AGEs are abnormally expressed in gestational hypertension, are closely related to the degree of condition, and have important clinical significance for condition control.

Highlights

Pregnancy-induced hypertension is a common disease in pregnancy, which mainly occurs after 20 weeks of pregnancy
The studies on the serum endothelial cell-specific molecular molecule-1 (ESM-1) and high molecular weight adiponectin (HMWA) associated with the occurrence of gestational hypertension are not enough
The pathogenesis of gestational hypertension is complex, which is mainly due to placental ischemia and vascular endothelial injury, increasing vascular permeability

Summary

Introduction

Pregnancy-induced hypertension is a common disease in pregnancy, which mainly occurs after 20 weeks of pregnancy. Proteinuria, and hypertension symptoms, which can lead to premature birth, postpartum bleeding, and other adverse pregnancy outcome. It can threat mother and infant life seriously [1]. ESM-1 is a novel marker associated with endothelial dysfunction, which is at normal levels in normal endothelial tissues. It is widely expressed in multiple cardiovascular diseases when levels of endothelial cells are elevated during periods of damage [2]. HMWA is the endogenous hormone polypeptide secreted by adipocytes and plays an important regulatory role in fatty acid oxidation and endothelial function [3].

Methods

Results

Conclusion