Serum Expression and Clinical Significance of Vascular Cell Adhesion Molecule-1 and MicroRNA-21 in Obstructive Sleep Apnea-Hypopnea Syndrome Patients in Chinese Population

Abstract

The aim of this study was to detect the expression level of vascular cell adhesion molecule-1 and MicroRNA-21 in peripheral serum of adult Obstructive Sleep Apnea-Hypopnea Syndrome patients and healthy subjects, analyze the correlation between vascular cell adhesion molecule-1/microRNA-21 and the main indicators of polysomnography (apnea-hypopnea index, L-Saturation of Peripheral Oxygen) of subjects. To explore the relationship between the expression of vascular cell adhesion molecule-1/microRNA-21 and the severity of Obstructive Sleep Apnea-Hypopnea Syndrome and its clinical significance. Total of week 50 Obstructive Sleep Apnea-Hypopnea Syndrome patients and 27 control cases were collected as study objects from December 2018 to December 2019 in our hospital. Enzyme-linked immunoassay was used to detect the vascular cell adhesion molecule-1 expression. Quantitative Reverse Transcription-polymerase chain reaction analysis was performed to determine the MicroRNA-21 expression. The weight, body mass index and apnea-hypopnea index were higher while L-Saturation of Peripheral Oxygen was lower in both Mild and the Moderate-severe group Obstructive Sleep Apnea-Hypopnea Syndrome patients than control cases. Besides, the serum expression of vascular cell adhesion molecule-1 and MicroRNA-21 were increased significantly in Obstructive Sleep Apnea-Hypopnea Syndrome patients, and the level was positively correlated with the degree of the disease. We also demonstrated that vascular cell adhesion molecule-1 and MicroRNA-21 had a positive correlation with weight, body mass index and apnea-hypopnea index, whereas a negative correlation with L-Saturation of Peripheral Oxygen. Finally, there is a significant positive correlation between vascular cell adhesion molecule-1 and MicroRNA-21. We have proved that the expression level of vascular cell adhesion molecule-1 and MicroRNA-21 in serum of subjects is closely related to apnea-hypopnea index and L-Saturation of Peripheral Oxygen, which can reflect the severity of Obstructive Sleep Apnea-Hypopnea Syndrome and may become a new biological observation index for diagnosis and prognosis evaluation of Obstructive Sleep Apnea-Hypopnea Syndrome.