Serum Cytokine Profile in Relation to the Severity of Coronary Artery Disease.

Xiaoyan Min,Sisi Pang,Sen Wang,Miao Lu,Kejiang Cao,Xiangming Wang,Jin Qian,Yan Guo,Chuanwei Zhou,Di Xu,Su Tu,Yiyue Ge

doi:10.1155/2017/4013685

Abstract

Objectives. To investigate the potential association of a set of serum cytokines with the severity of coronary artery disease (CAD). Methods. A total of 201 patients who underwent coronary angiography for chest discomfort were enrolled. The concentrations of serum IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-9, and IL-17 were determined by xMAP multiplex technology. The CAD severity was assessed by Gensini score (GS). Results. The serum levels of TNF-α, IL-6, IL-9, IL-10, and IL-17 were significantly higher in high GS group (GS ≥ 38.5) than those in low GS group (GS < 38.5). Positive correlations were also found between these cytokines and the severity of CAD. After adjustment for other associated factors, three serum cytokines (IL-6, IL-9, and IL-17) and two clinical risk factors (creatinine and LDL-C) were identified as the independent predictors of increased severity of CAD. ROC curve analysis revealed that the logistic regression risk prediction model had a good performance on predicting CAD severity. Conclusions. Combinatorial analysis of serum cytokines (IL-6, IL-9, and IL-17) with clinical risk factors (creatinine and LDL-C) may contribute to the evaluation of the severity of CAD and may help guide the risk stratification of angina patients, especially in primary health facilities and in the catheter lab resource-limited settings.

Highlights

Coronary artery disease (CAD) is the most prevalent chronic disease and a leading cause of morbidity and mortality worldwide [1]
It is widely acknowledged that the pathological basis of CAD is atherosclerosis, and inflammation plays a crucial role in atherosclerotic plaque progression, plaque rupture, and thrombosis, which are the initial factors in acute coronary syndrome (ACS) [4, 5]
The results revealed that the CAD severity as assessed by Gensini score (GS) was significantly and positively correlated with the levels of IL-6 (r = 0.511, P < 0.01), IL-9 (r = 0.534, P < 0.01), and IL-17 (r = 0.467, P < 0.01)

Summary

Introduction

Coronary artery disease (CAD) is the most prevalent chronic disease and a leading cause of morbidity and mortality worldwide [1]. It is widely acknowledged that the pathological basis of CAD is atherosclerosis, and inflammation plays a crucial role in atherosclerotic plaque progression, plaque rupture, and thrombosis, which are the initial factors in acute coronary syndrome (ACS) [4, 5]. This recognition has promoted the evaluation of the correlations between inflammatory markers and cardiovascular risk. Data have shown that interleukin-9 (IL-9) might mediate inflammatory cell infiltration into atherosclerotic lesions and may play a role in the atherosclerotic process [14, 15]

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Discussion

Conclusion