Abstract
Background: Acute kidney injury (AKI) is prevalent in hospitalized patients, primarily in patients undergoing major surgical procedures. AKI is associated with increased morbimortality, and patients would benefit from a very early diagnosis that would allow implementation of specific therapeutic or additional prophylactic measures. The present study evaluated serum cystatin C as an early predictor of AKI in elderly patients during the postoperative period. Methods: Fifty-nine patients, aged 60 years or older undergoing correction of femur fracture under spinal anaesthesia, were prospectively evaluated up to 48 hours after surgery. Serum cystatin C was measured immediately after surgery and four (early marker) and 24 hours after surgery. The diagnosis of AKI was based on creatinine values up to 48 hours after surgery (Kidney Disease Improving Global Outcomes, KDIGO), and the impact of serum cystatin C on the diagnosis of AKI was evaluated four hours after surgery.
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