Abstract
BackgroundHow to early distinguish the severity of Mycoplasma pneumoniae pneumonia (MPP) is a worldwide concern in clinical practice. We therefore conducted this study to assess the relationship between levels of serum inflammatory chemokines and the severity of MPP.Methods In this prospective study, we enrolled 39 children with MPP, whose clinical information was collected, blood samples were assayed for cytokines and chemokines by ELISA.ResultsThe levels of serum CXCL10 in children with severe MPP were significantly higher than those in children with mild MPP (2500.0 [1580.9–2500.0] vs. 675.7 [394.7–1134.9], P < 0.001). Measurement of CXCL10 levels in serum enabled the differentiation of children with severe MPP with an area under the curve (AUC) of 0.885 (95 % CI 0.779–0.991, P < 0.001), with a sensitivity of 81.0 % and a specificity of 83.3 %.ConclusionsSerum CXCL10 level may be a potential biomarker for severe MPP in children.
Highlights
How to early distinguish the severity of Mycoplasma pneumoniae pneumonia (MPP) is a worldwide concern in clinical practice
Clinical features of children with MPP In all, 39 children with MPP from the Children’s Hospital, Zhejiang University School of Medicine were recruited into our study
36 children were confirmed with MPP using BAL while 3 children were confirmed by nasopharyngeal swabs because they didn’t meet the indications for BAL, which are mentioned in the Methods
Summary
How to early distinguish the severity of Mycoplasma pneumoniae pneumonia (MPP) is a worldwide concern in clinical practice. Mycoplasma pneumoniae (MP) is among the smallest self-replicating bacteria that lack typical bacterial cell walls [1]. It is a common pathogenetic organism of respiratory infection in children. Chemokines with four subfamilies: CXC, CC, C and CX3C, are involved in many biological processes including tumor growth and metastasis, inflammation, angiogenesis, and migration of immune cells [4]. Based on their function, chemokines can be categorized into inflammatory, homeostatic and dual-function chemokines, as well. Inflammatory chemokines, including CXCL10/IFN-γinducible protein-10 (IP-10), CCL2, CCL5, CCL8, are found to be elevated under inflammatory conditions and
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