Abstract
Introduction: Chronic kidney disease (CKD) is a progressive decline in glomerular filtration rate (GFR) which is mainly caused by diabetic nephropathy and hypertension. Objectives: This study evaluated the relationship between changes in mean platelet volume (MPV) and serum creatinine levels. Patients and Methods: In this retrospective study, medical records of 100 patients with CKD including demographics data, medications, past-history, serum creatinine levels, and MPV were gathered. Additionally, we excluded patients who had a history of taking aspirin, idiopathic thrombocytopenic purpura, preeclampsia, sepsis, disseminated intravascular coagulation, aplastic anemia and administration of cytotoxic drugs. Results: This study was conducted on 100 CKD patients. Relationship between changes in MPV with serum creatinine level was evaluated by adjusting for gender, age, CKD stages, etiology, and weight. The changes in MPV and serum creatinine level were not significant with adjusting by underlying variables. However, in patients with high blood pressure, relationship of serum creatinine levels with MPV was inversely significant (r = -0.484, P =0.049). Conclusion: In CKD patients with high blood pressure, the changes in serum creatinine level have an inverse relationship with MPV. However, MPV is not an appropriate indicator for predicting of creatinine changes.
Highlights
Chronic kidney disease (CKD) is a progressive decline in glomerular filtration rate (GFR) which is mainly caused by diabetic nephropathy and hypertension
Implication for health policy/practice/research/medical education: In a study on 100 CKD patients, with hypertension, we found that changes in serum creatinine level have an inverse relationship with mean platelet volume (MPV)
CKD patients were classified based on serum creatinine level
Summary
Chronic kidney disease (CKD) is a progressive decline in glomerular filtration rate (GFR) which is mainly caused by diabetic nephropathy and hypertension. Objectives: This study evaluated the relationship between changes in mean platelet volume (MPV) and serum creatinine levels. Relationship between changes in MPV with serum creatinine level was evaluated by adjusting for gender, age, CKD stages, etiology, and weight. In patients with high blood pressure, relationship of serum creatinine levels with MPV was inversely significant (r = -0.484, P =0.049). Conclusion: In CKD patients with high blood pressure, the changes in serum creatinine level have an inverse relationship with MPV. Chronic kidney disease (CKD) is a progressive and irreversible deterioration of the renal excretory function and glomerular filtration rate (GFR) that results in implementation of renal replacement therapy (dialysis or renal transplant).
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