Abstract
Serum creatine phosphokinase isozymes were studied by agar gel electrophoresis in 7 cases of hypothyroidism, 5 cases of generalized convulsions, 4 cases of myocardial infarction, 7 cases of cerebrovascular disease, 3 cases of shock and 4 cases of other diseases. Sera of patients with myocardial infarction were found to have both the muscle type (MM) and muscle-brain hybrid type (MB) fractions, while sera of patients with generalized convulsions and skeletal muscle injuries were found to have only the MM fraction, in which the elevated creatine phosphokinase (CPK) is thought to be due to leakage from skeletal muscles. Only the MM type was seen in sera of patients with hypothyroidism, cerebrovascular disease, shock and some other diseases, in which the elevated serum CPK activities in these cases as well as in generalized convulsion and skeletal muscle injuries is thought to be also derived from the skeletal muscles. Our results suggest that serum CPK isozyme study is useful in identifying those organs responsible for the elevated serum CPK.
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