Abstract
It has been well documented that corin is a critical protease involved in the regulation of blood pressure and cardiac function. We performed a case-control study to determine whether serum corin is associated with the risk of chronic heart failure (CHF). We included 484 consecutive CHF patients and 484 control subjects to investigate the potential relationship between serum corin and CHF using logistic regression analysis. Compared with healthy controls, the CHF patients were more likely to have histories of hypertension and diabetes, and had higher levels of N-terminal pro-brain natriuretic peptide and lower levels of corin. The odds ratios of ischemic and non-ischemic HF were significantly reduced with the growing levels of serum corin after multivariate adjustment. Moreover, the decrease in serum corin levels seemed to be associated with the severity of CHF. In conclusion, our study suggested that serum corin levels were reduced in CHF patients and inversely correlated with the incidence of ischemic and non-ischemic HF.
Highlights
Corin is known as a transmembrane serine protease and has multiple physiological functions in the cardiovascular system
Our results showed that serum levels of corin were significantly decreased in chronic heart failure (CHF) patients
The Odds ratio (OR) of ischemic and non-ischemic HF were markedly reduced with the growing levels of serum corin following multivariate adjustment, which suggests that serum corin was inversely correlated with the incidence of CHF
Summary
Corin is known as a transmembrane serine protease and has multiple physiological functions in the cardiovascular system. This protease mainly exists in myocardial cells and plays crucial roles in processing pronatriuretic peptides, thereby regulating salt-water balance and vasodilation [1]. Overexpression of corin was found to improve cardiac function and survival in mice with dilated cardiomyopathy [3]. In population-based epidemiological studies, serum corin levels were found to be decreased in patients with acute myocardial infarction and stoke [4, 5]. We carried out a hospital-based case-control study to investigate the potential relationship between serum corin and CHF risk
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