Serum Copeptin Level and High-Sensitivity C-Reactive Protein in Centrally Obese Middle-Aged Male Subjects

Abstract

Background and Aim: Copeptin, a surrogate marker of Arginine Vasopressin, has been recently used as stress related neuroendocrine marker. In addition, chronic psychosocial stress had an association with increased inflammatory cytokines. Moreover, obesity has been recognized as high inflammatory status. Thus, it has been generated an interest whether centrally obese with high copeptin level have higher inflammatory status comparing to those with low copeptin level or not. Methods: Eighty-seven centrally obese male subjects between 40-60 years were recruited for this study. Anthropometric measurements such as height, weight, BMI and waist circumference were measured. Blood sample was collected to measure copeptin and hsCRP. Results: 29 subjects (33.33%) had low copeptin level (<5 pmol/L) and 58 subjects (66.67%) had high copeptin level (≥5 pmol/L). Median hs-CRP levels were 2.86 mg/L (IQR: 1.63-6.7) and 3.42 mg/L (IQR: 2.44-5.46) in obese with low copeptin level and obese with high copeptin level respectively. There was no significant difference in hs-CRP levels between these two study groups (p=0.7). Conclusion: In the study population of the present study, there was no correlation found between copeptin and inflammatory status.