Abstract
The aim of this study was to evaluate the risk of cervical cancer in relation to serum concentration of folate, vitamin B12 and homocysteine. Fifty patients with invasive cervical cancer and 50 VIA negative cases (control) with age range of 30-65 years were included. Majority of the patients had significantly low level of serum folate and B12 than those in the control group. In contrast, serum homocysteine level was significantly high in cases than those in the control group. The Pearson correlation coefficient test showed a significant negative relationship between serum folate, vitamin B12 and serum homocyteine. However, there was no significant association between stage of cervical cancer and level of serum homocysteine. In conclusion, a significantly low level of serum folate, vitamin B12 and high level of serum homocysteine were observed in patients with invasive cervical cancer.
Highlights
Cervical cancer is a disease of significant worldwide morbidity and mortality
Cervical cancer accounted for approximately 7.8% of all gynecological patients and 70% of all gynecological malignancies admitted in Bangabandhu Sheikh Mujib Medical University in the year 2007.6 Though cervical cancer is preventable, yet it is an important cause of disability and death of women in Bangladesh
Women who came to VIA center of Bangabandhu Sheikh Mujib Medical University for cervical cancer screening and diagnosed VIA negative were selected as controls
Summary
Cervical cancer is a disease of significant worldwide morbidity and mortality. There were about 530,000 new cases and 275,000 deaths due to cervical cancer worldwide.[1]. Cervical cancer accounted for approximately 7.8% of all gynecological patients and 70% of all gynecological malignancies admitted in Bangabandhu Sheikh Mujib Medical University in the year 2007.6 Though cervical cancer is preventable, yet it is an important cause of disability and death of women in Bangladesh
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