Serum concentration of acute phase proteins and cytokines in vaccinated pigs challenged with foot-and-mouth disease virus serotype O

Kyung-Woo Lee,Hyun S Lillehoj,Kwang-Nyeong Lee,Jong-Hyeon Park

doi:10.1590/rbz4820180190

Abstract

ABSTRACT The present study aimed to investigate the kinetics of acute phase proteins and cytokines in the serum of immunized or naive pigs following infection with a field isolate of foot-and-mouth disease (FMD) virus. Five-month-old SPF pigs were intramuscularly immunized with or without the 146S antigen (7.5 μg per head) purified from FMD virus (O/Andong/SKR/2010) and were subsequently challenged 30 days post-vaccination (dpv) with FMD virus on each footpad. Serum samples were obtained at 28 dpv and on days 1, [...]

Highlights

Foot-and-mouth disease (FMD) is a highly contagious viral disease that affects cloven-hoofed animals, including cattle, sheep, and pigs
The present study aimed to investigate the kinetics of acute phase proteins and cytokines in the serum of immunized or naive pigs following infection with a field isolate of foot-and-mouth disease (FMD) virus
It was observed that C-reactive protein (CRP), but not major acute phase protein (MAP), serum amyloid A (SAA), or haptoglobin, was increased in the immunized pigs at 28 dpv compared with the control pigs (Figure 1)

Summary

Introduction

Foot-and-mouth disease (FMD) is a highly contagious viral disease that affects cloven-hoofed animals, including cattle, sheep, and pigs. The South East Asia (SEA) topotype is the most prevalent in Asian countries, which commonly affected cattle and swine during the FMD outbreak in the East Asian region during 2010 and 2011 (Park et al, 2014). During this outbreak, direct economic losses were estimated to be 3 billion US$ (Sakamoto, 2012; Park et al, 2013; Saeed et al, 2015) due to the culling of 3.48 million susceptible animals. An inactivated oil-based vaccine has been developed using viruses of the O-SEA-topotype isolated in Korea and has demonstrated that vaccinated pigs (at least 7.5 μg antigen/pig) are effectively protected against homologous or heterologous viral challenge (Park et al, 2014).

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