Serum Citrin and γ-Glutamyl Transferase as Biomarkers for Infantile Cholestasis Severity

Abstract

One of the most important parameters to evaluate severity and type of cholestasis disease is gamma-glutamyl transferase and citrin protein measurements. The objective of this study was to assess the clinical value of serum citrin protein with gamma-glutamyl transferase in children with cholestasis. 60 subjects with diseases and 25 healthy subjects distributed intothree groups, citrinand gamma-glutamyl transferasewere measured for all case and control studies by enzyme linked immunosorbent Assay. The results showed serum citrin has a highly significantly decreased in an intra- and extrahepatic cholestasis groups when compared with control (P<0.001), serum gamma-glutamyl transferasehas a highly significantly elevated in an intrahepatic cholestasis group when compared with control (P<0.003). From these findings it was concluded that serum gamma-glutamyl transferase level is a good marker in determining the severity of cholestasis disease, serum citrin may be useful in future to diagnose the cholestasis caused by citrin deficiency.