Serum cholesteryl ester transfer protein concentrations in healthy Chinese subjects and cardio–cerebrovascular disease patients

Abstract

Serum cholesteryl ester transfer protein (CETP) concentration was measured in 1128 healthy Chinese subjects using a “sandwich” enzyme immunoassay and was 1.84±1.55 mg/l (mean±S.D.). The frequency distribution of CETP in healthy subjects was markedly skewed towards low concentrations. The CETP concentration in females was significantly higher than that in males (2.40±1.65 mg/l vs. 1.49±1.37 mg/l, P<0.001). There was a weak inverse correlation between the CETP concentration and age ( r=−0.19, P<0.001). The CETP concentrations were significantly higher in 117 myocardial infarction (MI) survivors and 110 stroke patients than that in 335 healthy, age-matched males (1.98±1.68 173±1.45, and 1.40±1.37 mg/l respectively, P<0.01), while no relation was found between CETP concentration and lipids concentration in MI, stroke and healthy group.