Abstract
The serum cholesterol lowering action of fermented milk with Streptococcus thermophilus TMC 1543 (1543FM), the mechanism behind the cholesterol lowering activity and the active factor in animal experiments were investigated using rats. The serum total cholesterol level of the group fed 1543FM was significantly lower than that of the control group (P<0.05). However, there were no serum cholesterol lowering activities in fermented milks with the other two lactic acid bacteria. The serum total cholesterol concentration of the group fed low-molecular-weight fraction (LMF) from 1543 FM was significantly lower than that of the control group (P<0.05). High-molecular-weight fraction (HMF) also tended to lower serum cholesterol level in the present animal study. The amounts of excretion of both total bile acid and neutral sterol in feces of the 1543FM group increased significantly in comparison with the control group (P<0.05). These results suggest that the mechanism behind serum cholesterol lowering activity of 1543FM would be attributable to the promotion of excretion of bile acid and neutral steroid through feces, and probably the low-molecular material in LMF.
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