Abstract
Objective: We evaluated serum chitotriosidase activity in patients with Wegener's granulomatosis (WG) and compared the values to controls. Design and Methods: We used a standard fluorometric assay to measure chitotriosidase enzyme activity. Results: Serum chitotriosidase enzyme activity levels were higher in WG patients. We found no association between clinical disease activity and chitotriosidase enzyme activity. Conclusions: Serum chitotriosidase enzyme activity has limited utility as a biomarker in WG patients.
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