Abstract
Background: Chemerin is an adipokine and a chemoattractant for leukocytes. Increased chemerin levels were observed in patients with coronary artery disease (CAD). We investigated associations between chemerin and biochemical measurements or body composition in CAD patients. Methods: In the study, we included patients with stable CAD who had undergone percutaneous coronary intervention (PCI) in the past. All patients had routine blood tests, and their insulin and chemerin serum levels were routinely measured. Body composition was assessed with the DEXA method. Results: The study group comprised 163 patients (mean age 59.8 ± years, 26% of females, n = 43). There was no significant difference in serum chemerin concentrations between patients with diabetes and the remaining ones: 306.8 ± 121 vs. 274.15 ± 109 pg/mL, p = 0.1. Chemerin correlated positively with the white blood cell (WBC) count, the neutrophil to lymphocyte ratio, hsCRP, all fractions of cholesterol, triglycerides, platelet count, fasting insulin, and c-peptide. Chemerin levels were also correlated with total fat mass but only in a subgroup with normal glucose metabolism. Conclusion: In patients with CAD, serum chemerin levels are correlated with inflammation markers, insulin resistance, and an unfavorable lipid profile. Correlation with fat mass is dependent on glucose metabolism status. Depending on the presence of diabetes/prediabetes, the mechanisms regulating chemerin secretion may be different.
Highlights
Chemerin is an adipokine and a chemoattractant for leukocytes
In our study performed in patients with chronic coronary syndromes, serum chemerin levels were associated with proinflammatory status, insulin resistance, and an unfavorable lipid profile
Serum chemerin levels were associated with inflammation markers
Summary
Chemerin is an adipokine and a chemoattractant for leukocytes. Increased chemerin levels were observed in patients with coronary artery disease (CAD). We investigated associations between chemerin and biochemical measurements or body composition in CAD patients. Chemerin is a protein that plays dual role as a chemoattractant for leukocyte populations and as an adipokine regulating lipid and carbohydrate metabolism and exerts proinflammatory action and promotes insulin resistance [1,2]. It binds to chemokine-like receptor 1 (CMKLR1), G protein-coupled receptor 1 (GPR1), and C-C motif receptor-like 2. Chemerin mediates its functions mainly via the CMKLR1 receptor, which is present mainly on dendritic cells, monocytes/macrophages, and adipocytes [3,4,5,6] (Figure 1)
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