Abstract
IntroductionAdipose tissue has been postulated to contribute substantially to the serum cholesteryl ester transfer protein (CETP) pool. However, in a recent large cohort study waist circumference was not associated with plasma CETP. The aim of the present study was to further examine associations of accurate measures of body fat and body fat distribution with serum CETP concentration. MethodsIn this cross-sectional analysis of the Netherlands Epidemiology of Obesity study, we examined in 6606 participants (aged 45–65 years) the associations of total body fat, body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), abdominal subcutaneous (aSAT) and visceral adipose tissue (VAT) assessed with magnetic resonance imaging (n = 2547) and total and trunk fat mass assessed with dual-energy X-ray absorptiometry (n = 909) with serum CETP concentration. Regression models were adjusted for age, ethnicity, sex, dietary intake of fat and cholesterol, physical activity, smoking and menopausal status. ResultsMean (SD) age was 56 (6) years and BMI 26.3 (4.4) kg/m2, 56% were women. Mean serum CETP concentration was 2.47 μg/mL. The difference in serum CETP was 0.02 μg/mL (95%CI: −0.01, 0.05) per SD total body fat (8.7%), and 0.02 μg/mL (0.00, 0.04) per SD BMI (4.4 kg/m2). Similar associations around the null were observed for waist circumference, WHR, aSAT, VAT, total and trunk fat mass. ConclusionIn this population-based study, there was no evidence for clinically relevant associations between several measures of body fat and serum CETP concentration. This finding implies that adipose tissue does not contribute to the CETP pool in serum.
Highlights
Adipose tissue has been postulated to contribute substantially to the serum cholesteryl ester transfer protein (CETP) pool
Based on the contradiction between findings of initial small studies reporting a positive relation between body fat and plasma Cholesteryl ester transfer protein (CETP) [12,14e18], and our recent finding that waist circumference was not associated with plasma CETP concentration [20], we aimed to further examine the contribution of adipose tissue to the serum CETP concentration in a large, population-based study
There was no evidence for clinically relevant associations between measures of body fat and serum CETP concentration as assessed by enzyme-linked immunosorbent assay (ELISA)
Summary
Adipose tissue has been postulated to contribute substantially to the serum cholesteryl ester transfer protein (CETP) pool. Methods: In this cross-sectional analysis of the Netherlands Epidemiology of Obesity study, we examined in 6606 participants (aged 45e65 years) the associations of total body fat, body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), abdominal subcutaneous (aSAT) and visceral adipose tissue (VAT) assessed with magnetic resonance imaging (n 1⁄4 2547) and total and trunk fat mass assessed with dual-energy X-ray absorptiometry (n 1⁄4 909) with serum CETP concentration. Conclusion: In this population-based study, there was no evidence for clinically relevant associations between several measures of body fat and serum CETP concentration. This finding implies that adipose tissue does not contribute to the CETP pool in serum. Inhibition of CETP expression in tissues contributing to the pool of plasma CETP may be an alternative approach, but the tissues and cell types responsible for determining plasma CETP levels are still not fully elucidated
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