Abstract
Type 2 diabetes mellitus is an endocrinological disease associated with hyperglycemia characterized by both insulin resistance and defective insulin secretion. Cardiovascular diseases are the peak reason for mortality in India, highest rate seen in Tamil Nadu state, from the age of 25 to 69 years. Many studies have revealed the importance of inflammatory pathway playing a pivotal role in the development and progression of diabetic complications. Ceruloplasmin, a copper containing mettalo-enzyme having antioxidant property (e.g ferroxidase activity) is an ideal marker to know the cardiovascular status, glycemic status, dyslipidemia and cancer risk. The purpose of the present study was to evaluate the effects of Body Mass Index (BMI) and Ceruloplasmin levels on the incidence of cardiovascular diseases in Type 2 Diabetes mellitus patients. Fasting Blood glucose, lipid profile which includes serum triglyceride, total cholesterol, LDL, VLDL, HDL and serum ceruloplasmin were investigated using fully automated chemistry analyzer. Diabetic patients were segregated into three groups based on their BMI, which was correlated with inflammatory marker ceruloplasmin to assess the cardiovascular risk. The mean value and standard deviation of ceruloplasminin controls (n=60) and diabetic cases divided into normal weight, over weight and obese (n=20 each) were 38.3±8.45, 36±7.99, 33.2±3.57and34.2±6.24 mg/dl respectively. Ceruloplasmin among the cases and controls were not statistically significant. Serum ceruloplasmin levels and BMI showed no correlation among the group 1 diabetic cases and was not significant (p=0.29), among the group 2diabetic cases it showed weak correlation and was not significant (p=0.85), and it also showed no correlation among the group 3 diabetic cases and was not significant (p=0.65).This study revealed no significant association between serum ceruloplasmin level and BMI in all diabetic group subjects separately.
Highlights
India, often called the diabetic capital stands first in the world ranking of countries with the highest number of diabetes patients
Serum ceruloplasmin levels and Body Mass Index (BMI) showed no correlation among the group 1 diabetic cases and was not significant (p=0.29), among the group 2diabetic cases it showed weak correlation and was not significant (p=0.85), and it showed no correlation among the group 3 diabetic cases and was not significant (p=0.65).This study revealed no significant association between serum ceruloplasmin level and BMI in all diabetic group subjects separately
Diabetes mellitus is a group of metabolic and endocrinological disorders with the phenotype of hyperglycemia caused by defective secretion of insulin and/or insulin resistance
Summary
Often called the diabetic capital stands first in the world ranking of countries with the highest number of diabetes patients. Diabetes mellitus is a group of metabolic and endocrinological disorders with the phenotype of hyperglycemia caused by defective secretion of insulin and/or insulin resistance. Type 2 diabetes mellitus is a disease characterized by hyperglycemia associated with insulin resistance.[1]. Cardiovascular disease that includes the deposition of atheromatous plaques in arteries and blood vessels of the heart is perhaps the most perilous diabetic complication, which is a cardinal reason for sudden mortality and morbidity among diabetic patients. In India it has become a major cause for mortality, being responsible for mortality estimates of 49% in Punjab,42%in Goa and 36% in Tamil Nadu.[2]
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