Abstract
OBJECTIVE: In this study, we aimed to study copper metabolism in schizophrenia, bipolar disorder, major depression compared with healthy control.METHODS: This is a single-centered cross-sec...
Highlights
Copper (Cu) is one of the most abundant elements among the transition metals
In this study, ceruloplasmin-ferroxidase activity is higher in all groups in comparison to the healthy control
The significantly higher ceruloplasmin-ferroxidase activity was shown in bipolar disorder followed by the major depression and schizophrenia
Summary
Copper (Cu) is one of the most abundant elements among the transition metals. It plays a critical physiological function as a component of proteins. It serves as the cofactor for numerous critical metalloenzymes involving the dopamine and norepinephrine metabolism. Cp is named as ferroxidase according to its ability for being an iron oxidase [4]. It plays an essential role in iron homeostasis through Cp-ferroxidase activity. Abnormal levels or insufficient functioning of Cp is found to be associated with iron and copper related pathologies [6,7]
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