Serum Ceramide Kinase as a Biomarker of Cognitive Functions, and the Effect of Using Two Slimming Dietary Therapies in Obese Middle Aged Females

Maha I A Moaty,Suzanne Fouad,Atiat M Arafa,Nihad H Ahmed,Salwa M El Shebini,Ahmed M S Hussein,Yusr M I Kazem,Salwa T Tapozada,Magda S Mohamed,Laila M Hanna

doi:10.3889/oamjms.2015.030

Maha I A Moaty, Suzanne Fouad + Show 8 more

Open Access

https://doi.org/10.3889/oamjms.2015.030

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Abstract

AIM:Highlighting the impact of obesity on mental and cognitive functions using serum ceramide kinase enzyme concentration as a biomarker for cognitive evaluation in the middle aged females, and also targeting to control the obesity and simultaneously postponing the deterioration of the cognitive functions, by implementing two slimming dietary therapies each incorporating different functional ingredients known to boost cognition.SUBJECTS AND METHODS:Ninety six obese middle aged females, divided into two groups volunteered to follow a low caloric balanced diet combined with two bread supplements composed essentially of barley flour and wheat germ mixed with either 5% turmeric, group (A); or with 5% ginger, group (B) for 4 weeks, phase (1); to be followed by the hypocaloric diet alone for another 4 weeks, phase (2).RESULTS:By the end of phase (1), the biochemical analysis showed a positive response of the levels of C-peptide and modified homeostatic model assessment of insulin resistance; also increased levels of the serum ceramide kinase enzyme, coupled with improved cognitive functions tests. Improvement of the relevant metabolic profile, fasting blood glucose, blood pressure and the anthropometric measurements was detected.CONCLUSION:Using dietary therapy supported by special formulas which contain active ingredients succeeded in reducing weight and improving both the metabolic profile and the cognitive functions.

Highlights

There is a direct relationship between middle age body weight and the risk of developing dementia later in life, with increased risk for the obese [1]
By the end of phase (1), the biochemical analysis showed a positive response of the levels of C-peptide and modified homeostatic model assessment of insulin resistance; increased levels of the serum ceramide kinase enzyme, coupled with improved cognitive functions tests
Using dietary therapy supported by special formulas which contain active ingredients succeeded in reducing weight and improving both the metabolic profile and the cognitive functions

Summary

Introduction

There is a direct relationship between middle age body weight and the risk of developing dementia later in life, with increased risk for the obese [1]. Dementia is a syndrome characterized by gradual decline in cognitive abilities and neuropsychiatric symptoms. Language, attention, judgment, planning, behavior, mood and personality. There is no cure for the cognitive decline and dementia; a cure may only be achieved by prevention. Dementia cases are potentially attributable to seven risk factors: diabetes, midlife hypertension, midlife obesity, depression, physical inactivity, smoking and cognitive inactivity [3]. Brookmeyer et al [4] further estimated that 3 million cases could be prevented worldwide by reducing the incidence of these risk factors by 25%

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