Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women

Stefan Kluzek,Anne-Christine Bay-Jensen,Andrew Judge,Morten A Karsdal,Matthew Shorthose,Tim Spector,Deborah Hart,Julia L Newton,Nigel K Arden

doi:10.3109/1354750x.2015.1105498

Abstract

Context and objective: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women.Materials and methods: Five hundred and ninety-three women with no baseline KOA underwent 5-year knee radiographs over 20-years and were asked about knee pain a month before each assessment. A repeated measures logistic regression model was used where the outcomes were recorded at 5, 10, 15 and 20-years follow-up.Results: The highest quartile of sCOMP was associated with increased risk of RKOA with overall OR of 1.97 (95% CI: 1.33–2.91) over 20 years when compared with the lowest sCOMP quartile. The association with painful KOA was similar and also independent, but only when the fourth and third sCOMP quartiles were compared.Discussion and conclusion: This study demonstrates that sCOMP levels are predictive of subsequent structural changes and incidence of painful KOA, independently of age and BMI.

Highlights

Knee osteoarthritis (KOA) is a highly prevalent disease of the largest synovial joint affecting quality of life, mobility and it is linked with an excess mortality (Cooper & Arden, 2011; Kluzek et al, 2015; Liu et al, 2015; Murphy et al, 2008; Nuesch et al, 2011; Semanik et al, 2015; Szoeke et al, 2006)
Context and objective: We evaluated the predictive value of serum cartilage oligomeric matrix protein levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women
The highest quartile of serum cartilage oligomeric matrix protein (sCOMP) was associated with increased risk of radiographic KOA (RKOA) with overall odds ratios (OR) of 1.97 over 20 years when compared with the lowest sCOMP quartile

Summary

Introduction

Knee osteoarthritis (KOA) is a highly prevalent disease of the largest synovial joint affecting quality of life, mobility and it is linked with an excess mortality (Cooper & Arden, 2011; Kluzek et al, 2015; Liu et al, 2015; Murphy et al, 2008; Nuesch et al, 2011; Semanik et al, 2015; Szoeke et al, 2006). COMP is derived from several tissue types, including cartilage, synovium and menisci, and composed of five equal subunits, each 110 kDa (Muller et al, 1998). It is synthesised by chondrocytes and synovial cells activated by proinflammatory cytokines (Zivanovicet al., 2011). Synovial COMP concentrations have been correlated with serum COMP (sCOMP) levels (Addison et al, 2009). The precise factors associated with variation of serum COMP levels remain incompletely understood. The results from The Johnston County Osteoarthritis Project demonstrate that ethnicity, sex and radiographic hip or knee changes are associated with variation of sCOMP levels (Jordan et al, 2003). Serum COMP levels increase significantly from 1 h after rising from bed and are affected by exercise (Kong et al, 2006; Neidhart et al, 2000)

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