Abstract
Rheumatoid Arthritis is a systemic autoimmune disease, characterized by chronic synovial inflammationleading to joint destruction and bone erosion. Metabolic changes have been studied in rheumatoid arthritis,with several studies reported decrease in serum calcium, and increase in serum alkaline phosphatase inrheumatoid arthritis patients in comparison to healthy individuals. This study has been undertaken toevaluate serum calcium and serum alkaline phosphatase levels in patients with rheumatoid arthritis, andtheir correlation with disease activity. A total of 100 patients with rheumatoid arthritis were enrolled in thestudy and compared with 50 healthy controls (46 female: 4 male) matched for age and sex. No significantdifferences have been noticed in mean values of serum calcium, corrected calcium, and serum alkalinephosphatase in patients with rheumatoid arthritis and healthy controls. The mean values of serum calcium,corrected calcium and serum alkaline phosphatase levels were slightly higher with moderate and high diseaseactivity in comparison to low disease activity in patients with rheumatoid arthritis, but the differences didnot reach the statistical significance.
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