Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance.

Wuquan Deng,Jie Zhao,Ling Li,Yuping Zhang,Changyan Li,Gangyi Yang,Bing Chen,Mengliu Yang,Mingyuan Tian,Yanling Zheng

doi:10.1186/s13098-015-0029-0

Abstract

BackgroundInsulin resistance (IR) correlates closely with cardiovascular disease. C1q/TNF-related protein-3 (CTRP3) is a novel adipokine that modulates insulin activity in various diseases. This study investigated the relationship between CTRP3 and IR as well as systemic inflammation in newly diagnosed obese and hypertensive patients (NCT02226471).MethodsSerum CTRP3 levels, anthropometric, inflammatory and metabolic parameters were measured in 180 obesity and essential hypertensive patients and in 66 normal weight, normotensive subjects.ResultsThe serum CTRP3 levels in the obesity group were lower than those in the NW group; these levels were also lower in hypertensive subjects than in normotensive subjects. After adjusting for gender, systolic blood pressure (SBP) and diastolic blood pressure (DBP), a modestly linear relationship was observed between CTRP3 and waist circumference (WC) (r = -0.168, p = 0.009), waist-to-hip ratio (WHR) (r = -0.183, p = 0.004), homeostasis model assessment of IR (HOMA-IR) (r = -0.264, p = 0.000), triglycerides (TG) (r = -0.136, p = 0.034), fasting blood glucose (FBG) (r = -0.155, p = 0.016), fasting insulin (FINS) (r = -0.248, p = 0.000) and homeostasis model assessment of β-cell insulin secretion (HOMA-β) (r = -0.128, p = 0.047). Multiple stepwise regression analysis revealed that gender, DBP and HOMA-IR were independently associated with serum CTRP3 levels.ConclusionCTRP3 was an independent factor affecting blood pressure and IR, and may play an important role in the pathogenesis of obesity and hypertension.

Highlights

Obesity has become a major global health problem, and the proportion of adults with overweight or obesity has increased substantially in the past thirty years [1]
The levels of waist-to-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), uric acid (UA), TG, total cholesterol (TC), white blood cell (WBC), HOMA-Insulin resistance (IR) and homeostasis model assessment of β-cell insulin secretion (HOMA-β) were higher in the normal weight (NW)-HTN subgroup than in the NW-normal blood pressure subgroup (NW-NBP) subgroup, and the levels of waist circumference (WC), WHR, SBP, DBP, TG and HOMAβ were higher in the obesity-hypertension subgroup (OB-HTN) subgroup than in the OBNBP subgroup
Compared with the NW-hypertension subgroup (NW-HTN) subgroup, the levels of body mass index (BMI), WC, WHR, UA, TG, fasting insulin (FINS), HOMAIR and HOMA-β were significantly increased in the OBHTN subgroup

Summary

Introduction

Obesity has become a major global health problem, and the proportion of adults with overweight or obesity has increased substantially in the past thirty years [1]. Obesity is considered one of the most important risk factors of cardiovascular disease [2]. Previous research has indicated that more than two-thirds of diagnosed hypertension can be directly attributed to obesity [3]. Recent studies have demonstrated that adipokines play important roles in the pathogenesis of obesity and function as a link between. A new and highly conserved family of secreted proteins, C1q/tumour necrosis factor-related proteins (CTRPs), which includes fifteen family members, was shown to possess structural homologies to adiponectin. C1q/TNF-related protein-3 (CTRP3), a member of the. Insulin resistance (IR) correlates closely with cardiovascular disease. C1q/TNF-related protein-3 (CTRP3) is a novel adipokine that modulates insulin activity in various diseases. This study investigated the relationship between CTRP3 and IR as well as systemic inflammation in newly diagnosed obese and hypertensive patients (NCT02226471)

Methods

Results

Discussion

Conclusion