Abstract
Night shift work is associated with cardiovascular disease and central nervous system disorders in female nurses. Brain-derived neurotrophic factor (BDNF) exerts protective effects on neural and endothelial functions. This study examined the association between serum BDNF levels and pulse pressure after rest in female nurses working night shifts. In this study, blood samples were collected for BDNF measurement after a night shift when nurses had been working night shifts for three continuous weeks. Blood pressure was assessed before and after a one-hour morning rest within a week of resuming the night shift after one month without any night shift work. The pulse pressure of nurses (n = 48, age 29 ± 5 years) was significantly reduced (from 43 ± 7 to 41 ± 6 mmHg, P = 0.003) after rest, and serum BDNF were significantly and inversely correlated with pulse pressure changes (r = −0.435, P = 0.002). Higher serum BDNF was an independent factor for greater reduction in pulse pressure (95%CI = −0.609 ‒ −0.174, P = 0.001). Using a receiver operating characteristic curve analysis, serum BDNF >20.6 ng/mL predicted a pulse pressure reduction after a one-hour rest (sensitivity 66.7%, specificity 77.8%). In conclusion, higher serum BDNF predicted greater recovery of pulse pressure after a one-hour rest in female nurses after night shift work.
Highlights
Night shift work is inevitable for nurses caring for inpatients
We examined the relationship between serum Brain-derived neurotrophic factor (BDNF) levels and changes in pulse pressure after a one-hour rest period in female nurses working night shifts
After rotating back to night shifts following a wash-out month, the subjects showed a significant reduction in the mean systolic pressure (112 ± 9 mmHg vs. 109 ± 9 mmHg, P = 0.002) after a one-hour rest period but not a significant change in the mean diastolic pressure (69 ± 7 mmHg vs. 68 ± 7 mmHg, P = 0.766)
Summary
Pooled data from the Nurses’ Health Study (NHS) I and NHS II show that approximately 60% of female nurses had experienced night shift work[1]. In other reports from the NHS I, night shift work was significantly associated with coronary heart disease and ischemic stroke in female nurses[3,4]. Night shift work was recently reported to be significantly associated with all-cause mortality and cardiovascular mortality in female nurses who were followed for 22 years[5]. Insufficient BDNF levels may play an important role in linking central nervous system disorders and arterial stiffness[20]. We examined the relationship between serum BDNF levels and changes in pulse pressure after a one-hour rest period in female nurses working night shifts
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