Abstract
Background: Pregnancy induces a number of physiological changes in the body including changes in bone profile. As the gestational period progresses and the foetus grows, its demand for mineral micronutrients increases inducing changes in the maternal body. Serum bone profile varies according to trimester as gestational period progresses. The study on which this article is based sought to determine changes in bone profile with trimester in pregnant women attending antenatal clinic at Parirenyatwa Group of Hospitals (PGH) and Chitungwiza Central Hospital, Zimbabwe. Method: An analytical cross sectional study was conducted on pregnant women attending antenatal clinics at Parirenyatwa Group of Hospitals and Chitungwiza Central Hospital. A questionnaire was administered and blood samples were collected for analysis of albumin, corrected calcium, phosphate and alkaline phosphatase. Results: A total of 171 pregnant women were recruited into the study. The albumin level showed a significant fall from trimester 1 to 2 (P<0.05) and an insignificant rise from trimester 2 to 3 (P>0.05). Conclusion: This study confirms the previously reported constant serum inorganic phosphate level throughout the gestational period and an increase in alkaline phosphatase with gestational age. Corrected calcium level had a statistically significant increase from the second to the third trimester (P<0.05). This study provided exploratory data on serum bone markers. Further research on more specific bone markers such as DEXA and bone specific alkaline phosphatase is required. A continual check of at risk women is needed to be able to advice on dietary supplementation to prevent premature osteoporosis.Bangladesh Journal of Medical Science Vol.14(4) 2015 p.363-366
Highlights
The ageing population has resulted in an increased burden of osteoporotic fractures, making it necessary to identify novel prevention strategies
Study procedure All pregnant women attending the antenatal clinics at Parirenyatwa Group of Hospitals and Chitungwiza Central Hospital during the study period were given information on the study
A total of 171 consenting pregnant women were recruited for the study from the antenatal clinics of the Parirenyatwa Group of Hospitals and Chitungwiza Central Hospital
Summary
The ageing population has resulted in an increased burden of osteoporotic fractures, making it necessary to identify novel prevention strategies. An analytical cross-sectional study was carried out on pregnant women attending antenatal clinics at Parirenyatwa Group of Hospitals and Chitungwiza Central Hospital, Zimbabwe. Study procedure All pregnant women attending the antenatal clinics at Parirenyatwa Group of Hospitals and Chitungwiza Central Hospital during the study period were given information on the study. Results A total of 171 consenting pregnant women were recruited for the study from the antenatal clinics of the Parirenyatwa Group of Hospitals and Chitungwiza Central Hospital. There was a statistically insignificant increase in the alkaline phosphatase plasma level from the first to the second trimester (P > 0.05) whilst the increase from the second to the third trimester was statistically significant (P < 0.05) as shown in Table 1 and Figure
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